Potentiation of an antimalarial oxidant drug
نویسندگان
چکیده
منابع مشابه
The apicoplast as an antimalarial drug target.
Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drug therapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that differ radically to those of the host ther...
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Chlorpheniramine, a histamine H1 receptor antagonist, was assayed for in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum K1 strain and chloroquine-resistant P. falciparum T9/94 clone, by measuring the 3H-hypoxanthine incorporation. Chlorphenirame inhibited P. falciparum K1 and T9/94 growth with IC50 values of 136.0+/-40.2 microM and 102.0+/-22.6 microM respectively...
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Antimalarial drug resistance is of great concern in the WHO South-East Asia (SEA) Region. A high degree of resistance of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine is prevalent in this Region. Multidrug resistance is prevalent in some parts of the Greater Mekong Sub-region. Artemisinin and its derivatives in combination with other effective partner drugs, which showed fa...
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Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. The de novo emergence of resistance can be prevented by ...
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26 1. Method and Search Strategy 28 2. Chloroquine 29 2.1 Mild and Moderate Adverse Effects 29 2.2 Severe Adverse Effects 30 2.3 Overdose Toxicity 30 2.4 Use in Pregnant Women 31 2.5 Use in Breast-Feeding Women 31 2.6 Contraindications and Cautions 31 3. Suifadoxine/Pyrimethamine 31 3.1 Miid and Moderate Adverse Effects 32 3.2 Severe Adverse Effects 32 3.2.1 Cutaneous Toxicity 32 3.2.2 Hepatic ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1997
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.41.7.1449